Fbxl2

  • Tumor Necrosis Factor Alpha Regulates Skeletal Myogenesis by Inhibiting SP1 Interaction with <em>cis</em>-Acting Regulatory Elements within the Fbxl2 Gene Promoter
    Research Article
    Tumor Necrosis Factor Alpha Regulates Skeletal Myogenesis by Inhibiting SP1 Interaction with cis-Acting Regulatory Elements within the Fbxl2 Gene Promoter

    Skeletal muscle regeneration and repair involve the recruitment and proliferation of resident satellite cells that exit the cell cycle during the process of myogenic differentiation to form myofibers. We demonstrate that the ubiquitin E3 ligase subunit FBXL2 is essential for skeletal myogenesis through its important effects on cell cycle progression and cell proliferative signaling. Further, we characterize a new mechanism whereby...

    Michael E. O’Brien, James Londino, Marcus McGinnis, Nathaniel Weathington, Jessica Adair, Tomeka Suber, Valerian Kagan, Kong Chen, Chunbin Zou, Bill Chen, Jessica Bon, Rama K. Mallampalli
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