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fibrosis

  • Critical Role of Matrix Metalloproteinase 14 in Adipose Tissue Remodeling during Obesity
    Research Article | Spotlight
    Critical Role of Matrix Metalloproteinase 14 in Adipose Tissue Remodeling during Obesity

    Fibrosis is recognized as the major pathological change in adipose tissue during the development of obesity. However, the detailed mechanisms governing the interactions between the fibrotic components and their modifiers remain largely unclear. Here, we reported that matrix metalloproteinase 14 (MMP14), a key pericellular collagenase, is dramatically upregulated in obese adipose tissue. We generated a doxycycline-inducible adipose...

    Xin Li, Yueshui Zhao, Chuan Chen, Li Yang, Hyun-ho Lee, Zening Wang, Ningyan Zhang, Mikhail G. Kolonin, Zhiqiang An, Xin Ge, Philipp E. Scherer, Kai Sun
  • Research Article
    Sav1 Loss Induces Senescence and Stat3 Activation Coinciding with Tubulointerstitial Fibrosis
    Janet Y. Leung, Harper L. Wilson, Kristin J. Voltzke, Lindsay A. Williams, Hyo Jin Lee, Sara E. Wobker, William Y. Kim
  • Research Article
    LIM-Only Protein FHL2 Is a Negative Regulator of Transforming Growth Factor β1 Expression
    Jennifer Dahan, Florence Levillayer, Tian Xia, Yann Nouët, Catherine Werts, Martine Fanton d'Andon, Minou Adib-Conquy, Anne-Marie Cassard-Doulcier, Varun Khanna, Ju Chen, Thierry Tordjmann, Marie-Annick Buendia, Grégory Jouvion, Yu Wei
  • Research Article
    A High-Fat Diet Promotes Mammary Gland Myofibroblast Differentiation through MicroRNA 140 Downregulation
    Benjamin Wolfson, Yongshu Zhang, Ramkishore Gernapudi, Nadire Duru, Yuan Yao, Pang-Kuo Lo, Qun Zhou
  • Articles
    Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue
    Nils Halberg, Tayeba Khan, Maria E. Trujillo, Ingrid Wernstedt-Asterholm, Alan D. Attie, Shariq Sherwani, Zhao V. Wang, Shira Landskroner-Eiger, Sean Dineen, Ulysses J. Magalang, Rolf A. Brekken, Philipp E. Scherer
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