gene deletion

  • Germ Line Deletion Reveals a Nonessential Role of Atypical Mitogen-Activated Protein Kinase 6/Extracellular Signal-Regulated Kinase 3
    Research Article | Spotlight
    Germ Line Deletion Reveals a Nonessential Role of Atypical Mitogen-Activated Protein Kinase 6/Extracellular Signal-Regulated Kinase 3

    Mitogen-activated protein kinase 6/extracellular signal-regulated kinase 3 (MAPK6/ERK3) is an atypical member of the MAPKs. An essential role has been suggested by the perinatal lethal phenotype of ERK3 knockout mice carrying a lacZ insertion in exon 2 due to pulmonary dysfunction and by defects in function, activation, and positive selection of T cells.

    N. Ronkina, K. Schuster-Gossler, F. Hansmann, H. Kunze-Schumacher, I. Sandrock, T. Yakovleva, J. Lafera, W. Baumgärtner, A. Krueger, I. Prinz, A. Gossler, A. Kotlyarov, M. Gaestel
Back to top