histones
Research ArticleA Conserved Histone H3-H4 Interface Regulates DNA Damage Tolerance and Homologous Recombination during the Recovery from Replication StressIn eukaryotes, genomic DNA is packaged into nucleosomes, which are the basal components coordinating both the structures and functions of chromatin. In this study, we screened a collection of mutations for histone H3/H4 mutants in Saccharomyces cerevisiae that affect the DNA damage sensitivity of DNA damage tolerance (DDT)-deficient cells.
Research ArticleThe N-Terminal Tail of Histone H3 Regulates Copper Homeostasis in Saccharomyces cerevisiaeCopper homeostasis is crucial for cellular processes. The balance between nutritional and toxic levels is maintained through the regulation of uptake, distribution, and detoxification via antagonistic actions of two transcription factors, AceI and Mac1.
- Research Article | SpotlightIdentification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level γ-Globin Gene Expression
The organization of the five β-type globin genes on chromosome 11 reflects the timing of expression during erythroid cell development, with the embryonic ε-globin gene being located at the 5′ end, followed by the two fetal γ-globin genes, and with the adult β- and δ-globin genes being located at the 3′ end. Here, we functionally characterized a DNase I-hypersensitive site (HS) located 4 kb upstream of the Gγ-globin gene (HBG-4kb HS)....
- Articles | SpotlightGenome-Wide Distribution of MacroH2A1 Histone Variants in Mouse Liver Chromatin