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histones

  • A Conserved Histone H3-H4 Interface Regulates DNA Damage Tolerance and Homologous Recombination during the Recovery from Replication Stress
    Research Article
    A Conserved Histone H3-H4 Interface Regulates DNA Damage Tolerance and Homologous Recombination during the Recovery from Replication Stress

    In eukaryotes, genomic DNA is packaged into nucleosomes, which are the basal components coordinating both the structures and functions of chromatin. In this study, we screened a collection of mutations for histone H3/H4 mutants in Saccharomyces cerevisiae that affect the DNA damage sensitivity of DNA damage tolerance (DDT)-deficient cells.

    Masafumi Hayashi, Kenji Keyamura, Asami Yoshida, Mariko Ariyoshi, Genki Akanuma, Takashi Hishida
  • The N-Terminal Tail of Histone H3 Regulates Copper Homeostasis in <span class="named-content genus-species" id="named-content-1">Saccharomyces cerevisiae</span>
    Research Article
    The N-Terminal Tail of Histone H3 Regulates Copper Homeostasis in Saccharomyces cerevisiae

    Copper homeostasis is crucial for cellular processes. The balance between nutritional and toxic levels is maintained through the regulation of uptake, distribution, and detoxification via antagonistic actions of two transcription factors, AceI and Mac1.

    Sakshi Singh, Rakesh Kumar Sahu, Raghuvir Singh Tomar
  • Open Access
    Research Article | Spotlight
    Identification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level γ-Globin Gene Expression

    The organization of the five β-type globin genes on chromosome 11 reflects the timing of expression during erythroid cell development, with the embryonic ε-globin gene being located at the 5′ end, followed by the two fetal γ-globin genes, and with the adult β- and δ-globin genes being located at the 3′ end. Here, we functionally characterized a DNase I-hypersensitive site (HS) located 4 kb upstream of the Gγ-globin gene (HBG-4kb HS)....

    Yong Shen, MacLean A. Bassett, Aishwarya Gurumurthy, Rukiye Nar, Isaac J. Knudson, Cameron R. Guy, Alex Perez, Russell W. Mellen, Masatoshi Ikeda, Mir A. Hossain, Suming Huang, Kazuhiko Igarashi, Jörg Bungert
  • Open Access
    Research Article
    mRNA Processing Factor CstF-50 and Ubiquitin Escort Factor p97 Are BRCA1/BARD1 Cofactors Involved in Chromatin Remodeling during the DNA Damage Response
    Danae Fonseca, Jorge Baquero, Michael R. Murphy, Gamage Aruggoda, Sophia Varriano, Carmen Sapienza, Oksana Mashadova, Shadaqur Rahman, Frida E. Kleiman
  • Research Article
    Tet-Mediated DNA Demethylation Is Required for SWI/SNF-Dependent Chromatin Remodeling and Histone-Modifying Activities That Trigger Expression of the Sp7 Osteoblast Master Gene during Mesenchymal Lineage Commitment
    Hugo Sepulveda, Alejandro Villagra, Martin Montecino
  • Research Article
    EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice
    Yixin Dong, Kyo-ichi Isono, Kazuyuki Ohbo, Takaho A. Endo, Osamu Ohara, Mamiko Maekawa, Yoshiro Toyama, Chizuru Ito, Kiyotaka Toshimori, Kristian Helin, Narumi Ogonuki, Kimiko Inoue, Atsuo Ogura, Kazutsune Yamagata, Issay Kitabayashi, Haruhiko Koseki
  • Research Article
    The Drosophila DAXX-Like Protein (DLP) Cooperates with ASF1 for H3.3 Deposition and Heterochromatin Formation
    Catherine Fromental-Ramain, Philippe Ramain, Ali Hamiche
  • Research Article
    SETD4 Regulates Cell Quiescence and Catalyzes the Trimethylation of H4K20 during Diapause Formation in Artemia
    Li Dai, Sen Ye, Hua-Wei Li, Dian-Fu Chen, Hong-Liang Wang, Sheng-Nan Jia, Cheng Lin, Jin-Shu Yang, Fan Yang, Hiromichi Nagasawa, Wei-Jun Yang
  • Articles | Spotlight
    Genome-Wide Distribution of MacroH2A1 Histone Variants in Mouse Liver Chromatin
    Lakshmi N. Changolkar, Geetika Singh, Kairong Cui, Joel B. Berletch, Keji Zhao, Christine M. Disteche, John R. Pehrson
  • Articles
    Chromatin Loading of E2F-MLL Complex by Cancer-Associated Coregulator ANCCA via Reading a Specific Histone Mark
    Alexey S. Revenko, Ekaterina V. Kalashnikova, Abigael T. Gemo, June X. Zou, Hong-Wu Chen

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