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iron

  • Iron Supply via NCOA4-Mediated Ferritin Degradation Maintains Mitochondrial Functions
    Research Article
    Iron Supply via NCOA4-Mediated Ferritin Degradation Maintains Mitochondrial Functions

    Iron is an essential nutrient for mitochondrial metabolic processes, including mitochondrial respiration. Ferritin complexes store excess iron and protect cells from iron toxicity. Therefore, iron stored in the ferritin complex might be utilized under iron-depleted conditions.

    Motoki Fujimaki, Norihiko Furuya, Shinji Saiki, Taku Amo, Yoko Imamichi, Nobutaka Hattori
  • Generation and Molecular Characterization of Human Ring Sideroblasts: a Key Role of Ferrous Iron in Terminal Erythroid Differentiation and Ring Sideroblast Formation
    Research Article
    Generation and Molecular Characterization of Human Ring Sideroblasts: a Key Role of Ferrous Iron in Terminal Erythroid Differentiation and Ring Sideroblast Formation

    Ring sideroblasts are a hallmark of sideroblastic anemia, although little is known about their characteristics. Here, we first generated mutant mice by disrupting the GATA-1 binding motif at the intron 1 enhancer of the ALAS2 gene, a gene responsible for X-linked sideroblastic anemia (XLSA).

    Kei Saito, Tohru Fujiwara, Shunsuke Hatta, Masanobu Morita, Koya Ono, Chie Suzuki, Noriko Fukuhara, Yasushi Onishi, Yukio Nakamura, Shin Kawamata, Ritsuko Shimizu, Masayuki Yamamoto, Hideo Harigae
  • Articles
    Regulation of Mitochondrial Iron Import through Differential Turnover of Mitoferrin 1 and Mitoferrin 2
    Prasad N. Paradkar, Kimberley B. Zumbrennen, Barry H. Paw, Diane M. Ward, Jerry Kaplan
  • Articles
    Dre2, a Conserved Eukaryotic Fe/S Cluster Protein, Functions in Cytosolic Fe/S Protein Biogenesis
    Yan Zhang, Elise R. Lyver, Eiko Nakamaru-Ogiso, Heeyong Yoon, Boominathan Amutha, Dong-Woo Lee, Erfei Bi, Tomoko Ohnishi, Fevzi Daldal, Debkumar Pain, Andrew Dancis
  • Articles
    Human Nbp35 Is Essential for both Cytosolic Iron-Sulfur Protein Assembly and Iron Homeostasis
    Oliver Stehling, Daili J. A. Netz, Brigitte Niggemeyer, Ralf Rösser, Richard S. Eisenstein, Helene Puccio, Antonio J. Pierik, Roland Lill
  • Articles
    Yap5 Is an Iron-Responsive Transcriptional Activator That Regulates Vacuolar Iron Storage in Yeast
    Liangtao Li, Dustin Bagley, Diane M. Ward, Jerry Kaplan
  • Articles
    Iron-Dependent Degradation of Apo-IRP1 by the Ubiquitin-Proteasome Pathway
    Jian Wang, Carine Fillebeen, Guohua Chen, Annette Biederbick, Roland Lill, Kostas Pantopoulos
  • Articles
    Role of Human Mitochondrial Nfs1 in Cytosolic Iron-Sulfur Protein Biogenesis and Iron Regulation
    Annette Biederbick, Oliver Stehling, Ralf Rösser, Brigitte Niggemeyer, Yumi Nakai, Hans-Peter Elsässer, Roland Lill
  • Articles
    Sodium Nitroprusside Promotes IRP2 Degradation via an Increase in Intracellular Iron and in the Absence of S Nitrosylation at C178
    Jian Wang, Carine Fillebeen, Guohua Chen, Bill Andriopoulos, Kostas Pantopoulos
  • GENE EXPRESSION
    Direct Activation of Genes Involved in Intracellular Iron Use by the Yeast Iron-Responsive Transcription Factor Aft2 without Its Paralog Aft1
    Maïté Courel, Sylvie Lallet, Jean-Michel Camadro, Pierre-Louis Blaiseau

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