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Islets of Langerhans

  • Morphogenesis of the Islets of Langerhans Is Guided by Extraendocrine Slit2 and Slit3 Signals
    Research Article | Spotlight
    Morphogenesis of the Islets of Langerhans Is Guided by Extraendocrine Slit2 and Slit3 Signals

    The spatial architecture of the islets of Langerhans is vitally important for their correct function, and alterations in islet morphogenesis often result in diabetes mellitus. We have previously reported that Roundabout (Robo) receptors are required for proper islet morphogenesis.

    Jennifer M. Gilbert, Melissa T. Adams, Nadav Sharon, Hariharan Jayaraaman, Barak Blum
  • Articles
    Hnf1α (MODY3) Controls Tissue-Specific Transcriptional Programs and Exerts Opposed Effects on Cell Growth in Pancreatic Islets and Liver
    Joan-Marc Servitja, Miguel Pignatelli, Miguel Ángel Maestro, Carina Cardalda, Sylvia F. Boj, Juanjo Lozano, Enrique Blanco, Amàlia Lafuente, Mark I. McCarthy, Lauro Sumoy, Roderic Guigó, Jorge Ferrer
  • Articles
    Peroxisome Proliferator-Activated Receptor γ Activation Restores Islet Function in Diabetic Mice through Reduction of Endoplasmic Reticulum Stress and Maintenance of Euchromatin Structure
    Carmella Evans-Molina, Reiesha D. Robbins, Tatsuyoshi Kono, Sarah A. Tersey, George L. Vestermark, Craig S. Nunemaker, James C. Garmey, Tye G. Deering, Susanna R. Keller, Bernhard Maier, Raghavendra G. Mirmira
  • Articles
    Histone Deacetylase Inhibitors Modify Pancreatic Cell Fate Determination and Amplify Endocrine Progenitors
    Cécile Haumaitre, Olivia Lenoir, Raphaël Scharfmann
  • Articles
    Aquaporin 7 Is a β-Cell Protein and Regulator of Intraislet Glycerol Content and Glycerol Kinase Activity, β-Cell Mass, and Insulin Production and Secretion
    Kazuhiro Matsumura, Benny Hung-Junn Chang, Mineko Fujimiya, Weiqin Chen, Rohit N. Kulkarni, Yutaka Eguchi, Hiroshi Kimura, Hideto Kojima, Lawrence Chan
  • Articles
    Regulation of Insulin Secretion and β-Cell Mass by Activating Signal Cointegrator 2
    Seon-Yong Yeom, Geun Hyang Kim, Chan Hee Kim, Heun Don Jung, So-Yeon Kim, Joong-Yeol Park, Youngmi Kim Pak, Dong-Kwon Rhee, Shao-Qing Kuang, Jianming Xu, Duck Jong Han, Dae-Kyu Song, Jae Woon Lee, Ki-Up Lee, Seung-Whan Kim
  • Articles
    Essential Role of Pten in Body Size Determination and Pancreatic β-Cell Homeostasis In Vivo
    Kinh-Tung T. Nguyen, Panteha Tajmir, Chia Hung Lin, Nicole Liadis, Xu-Dong Zhu, Mohammed Eweida, Gunce Tolasa-Karaman, Fang Cai, Rennian Wang, Tadahiro Kitamura, Denise D. Belsham, Michael B. Wheeler, Akira Suzuki, Tak W. Mak, Minna Woo
  • MAMMALIAN GENETIC MODELS WITH MINIMAL OR COMPLEX PHENOTYPES
    Abnormal Glucose Homeostasis and Pancreatic Islet Function in Mice with Inactivation of the Fem1b Gene
    Deyin Lu, Tereza Ventura-Holman, Jing Li, Robert W. McMurray, Jose S. Subauste, Joseph F. Maher
  • MAMMALIAN GENETIC MODELS WITH MINIMAL OR COMPLEX PHENOTYPES
    MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion
    Chuan Zhang, Takashi Moriguchi, Miwako Kajihara, Ritsuko Esaki, Ayako Harada, Homare Shimohata, Hisashi Oishi, Michito Hamada, Naoki Morito, Kazuteru Hasegawa, Takashi Kudo, James Douglas Engel, Masayuki Yamamoto, Satoru Takahashi
  • SIGNAL TRANSDUCTION
    Cyclins D2 and D1 Are Essential for Postnatal Pancreatic β-Cell Growth
    Jake A. Kushner, Maria A. Ciemerych, Ewa Sicinska, Lynn M. Wartschow, Monica Teta, Simon Y. Long, Piotr Sicinski, Morris F. White

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