LINE-1

  • Open Access
    Dynamic Methylation of an L1 Transduction Family during Reprogramming and Neurodifferentiation
    Research Article
    Dynamic Methylation of an L1 Transduction Family during Reprogramming and Neurodifferentiation

    The retrotransposon LINE-1 (L1) is a significant source of endogenous mutagenesis in humans. In each individual genome, a few retrotransposition-competent L1s (RC-L1s) can generate new heritable L1 insertions in the early embryo, primordial germ line, and germ cells.

    Carmen Salvador-Palomeque, Francisco J. Sanchez-Luque, Patrick R. J. Fortuna, Adam D. Ewing, Ernst J. Wolvetang, Sandra R. Richardson, Geoffrey J. Faulkner
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