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liver

  • STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes
    Research Article | Spotlight
    STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes

    Growth hormone-activated STAT5b is an essential regulator of sex-differential gene expression in mouse liver; however, its impact on hepatic gene expression and epigenetic responses is poorly understood. Here, we found a substantial, albeit incomplete loss of liver sex bias in hepatocyte-specific STAT5a/STAT5b (collectively, STAT5)-deficient mouse liver.

    Pengying Hao, David J. Waxman
  • Research Article | Spotlight
    Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver
    Sung E. Choi, Sanghoon Kwon, Sunmi Seok, Zhen Xiao, Kwan-Woo Lee, Yup Kang, Xiaoling Li, Kosaku Shinoda, Shingo Kajimura, Byron Kemper, Jongsook Kim Kemper
  • Open Access
    Research Article
    Gs-DREADD Knock-In Mice for Tissue-Specific, Temporal Stimulation of Cyclic AMP Signaling
    Dmitry Akhmedov, Maria G. Mendoza-Rodriguez, Kavitha Rajendran, Mario Rossi, Jürgen Wess, Rebecca Berdeaux
  • Articles | Spotlight
    Genome-Wide Distribution of MacroH2A1 Histone Variants in Mouse Liver Chromatin
    Lakshmi N. Changolkar, Geetika Singh, Kairong Cui, Joel B. Berletch, Keji Zhao, Christine M. Disteche, John R. Pehrson
  • Articles
    Unbiased, Genome-Wide In Vivo Mapping of Transcriptional Regulatory Elements Reveals Sex Differences in Chromatin Structure Associated with Sex-Specific Liver Gene Expression
    Guoyu Ling, Aarathi Sugathan, Tali Mazor, Ernest Fraenkel, David J. Waxman
  • Articles
    Forkhead Box M1 Transcription Factor Is Required for Macrophage Recruitment during Liver Repair
    Xiaomeng Ren, Yufang Zhang, Jonathan Snyder, Emily R. Cross, Tushar A. Shah, Tanya V. Kalin, Vladimir V. Kalinichenko
  • Articles | Spotlight
    Krüppel-Like Factor KLF10 Is a Link between the Circadian Clock and Metabolism in Liver
    Fabienne Guillaumond, Aline Gréchez-Cassiau, Malayannan Subramaniam, Sophie Brangolo, Brigitta Peteri-Brünback, Bart Staels, Catherine Fiévet, Thomas C. Spelsberg, Franck Delaunay, Michèle Teboul
  • Articles
    Hepatocyte Nuclear Factor 4α Coordinates a Transcription Factor Network Regulating Hepatic Fatty Acid Metabolism
    Celia Pilar Martinez-Jimenez, Irene Kyrmizi, Philippe Cardot, Frank J. Gonzalez, Iannis Talianidis
  • Articles
    Dyskerin Ablation in Mouse Liver Inhibits rRNA Processing and Cell Division
    Jingping Ge, David A. Rudnick, Jun He, Dan L. Crimmins, Jack H. Ladenson, Monica Bessler, Philip J. Mason
  • Articles
    Peroxisome Proliferator-Activated Receptor β/δ (PPARβ/δ) but Not PPARα Serves as a Plasma Free Fatty Acid Sensor in Liver
    Linda M. Sanderson, Tatjana Degenhardt, Arjen Koppen, Eric Kalkhoven, Beatrice Desvergne, Michael Müller, Sander Kersten

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