macrophage

  • Therapeutic IDOL Reduction Ameliorates Amyloidosis and Improves Cognitive Function in APP/PS1 Mice
    Research Article | Spotlight
    Therapeutic IDOL Reduction Ameliorates Amyloidosis and Improves Cognitive Function in APP/PS1 Mice

    Brain lipoprotein receptors have been shown to regulate the metabolism of ApoE and β-amyloid (Aβ) and are potential therapeutic targets for Alzheimer’s disease (AD). Previously, we identified E3 ubiquitin ligase IDOL as a negative regulator of brain lipoprotein receptors. Genetic ablation of Idol increases low-density lipoprotein receptor protein levels, which facilitates Aβ uptake and clearance by microglia. In this study, we...

    Jie Gao, Russell Littman, Graciel Diamante, Xu Xiao, In Sook Ahn, Xia Yang, Tracy A. Cole, Peter Tontonoz
  • Inflammation Triggers Liver X Receptor-Dependent Lipogenesis
    Research Article | Spotlight
    Inflammation Triggers Liver X Receptor-Dependent Lipogenesis

    Immune cell function can be modulated by changes in lipid metabolism. Our studies indicate that cholesterol and fatty acid synthesis increases in macrophages between 12 and 18 h after the activation of Toll-like receptors with proinflammatory stimuli and that the upregulation of lipogenesis may contribute to the resolution of inflammation.

    Sophie R. Liebergall, Jerry Angdisen, Shun Hang Chan, YingJu Chang, Timothy F. Osborne, Alexander F. Koeppel, Stephen D. Turner, Ira G. Schulman
  • PIKfyve Deficiency in Myeloid Cells Impairs Lysosomal Homeostasis in Macrophages and Promotes Systemic Inflammation in Mice
    Research Article
    PIKfyve Deficiency in Myeloid Cells Impairs Lysosomal Homeostasis in Macrophages and Promotes Systemic Inflammation in Mice

    Macrophages are professional phagocytes that are essential for host defense and tissue homeostasis. Proper membrane trafficking and degradative functions of the endolysosomal system are known to be critical for the function of these cells. We have found that PIKfyve, the kinase that synthesizes the endosomal phosphoinositide phosphatidylinositol-3,5-bisphosphate, is an essential regulator of lysosomal biogenesis and degradative...

    Sang Hee Min, Aae Suzuki, Lehn Weaver, Jessica Guzman, Yutein Chung, Huiyan Jin, Francina Gonzalez, Claire Trasorras, Liang Zhao, Lynn A. Spruce, Steven H. Seeholzer, Edward M. Behrens, Charles S. Abrams
  • Common and Differential Transcriptional Actions of Nuclear Receptors Liver X Receptors α and β in Macrophages
    Research Article
    Common and Differential Transcriptional Actions of Nuclear Receptors Liver X Receptors α and β in Macrophages

    The liver X receptors α and β (LXRα and LXRβ) are oxysterol-activated transcription factors that coordinately regulate gene expression that is important for cholesterol and fatty acid metabolism. In addition to their roles in lipid metabolism, LXRs participate in the transcriptional regulation of macrophage activation and are considered potent regulators of inflammation.

    Ana Ramón-Vázquez, Juan Vladimir de la Rosa, Carlos Tabraue, Felix Lopez, Bonifacio Nicolas Díaz-Chico, Lisardo Bosca, Peter Tontonoz, Susana Alemany, Antonio Castrillo
  • Research Article | Spotlight
    CITED2 Restrains Proinflammatory Macrophage Activation and Response
    Gun-Dong Kim, Riku Das, Xiaoquan Rao, Jixin Zhong, Jeffrey A. Deiuliis, Diana L. Ramirez-Bergeron, Sanjay Rajagopalan, Ganapati H. Mahabeleshwar
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