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macrophages

  • Unraveling the Hierarchy of <em>cis</em> and <em>trans</em> Factors That Determine the DNA Binding by Peroxisome Proliferator-Activated Receptor γ
    Research Article | Spotlight
    Unraveling the Hierarchy of cis and trans Factors That Determine the DNA Binding by Peroxisome Proliferator-Activated Receptor γ

    Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor essential for adipocyte development and the maintenance of the alternatively polarized macrophage phenotype. Biochemical studies have established that as an obligate heterodimer with retinoid X receptor (RXR), PPARγ binds directly repeated nuclear receptor half sites spaced by one nucleotide (direct repeat 1 [DR1]). However, it has not been analyzed...

    Gergely Nagy, Bence Daniel, Ixchelt Cuaranta-Monroy, Laszlo Nagy
  • Open Access
    Inhibition of tRNA Gene Transcription by the Immunosuppressant Mycophenolic Acid
    Research Article | Spotlight
    Inhibition of tRNA Gene Transcription by the Immunosuppressant Mycophenolic Acid

    Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil, a drug that is widely used for immunosuppression in organ transplantation and autoimmune diseases, as well as anticancer chemotherapy. It inhibits IMP dehydrogenase, a rate-limiting enzyme in de novo synthesis of guanidine nucleotides.

    Aneta Jurkiewicz, Ewa Leśniewska, Małgorzata Cieśla, Neuton Gorjão, Theodoros Kantidakis, Robert J. White, Magdalena Boguta, Damian Graczyk
  • PIKfyve Deficiency in Myeloid Cells Impairs Lysosomal Homeostasis in Macrophages and Promotes Systemic Inflammation in Mice
    Research Article
    PIKfyve Deficiency in Myeloid Cells Impairs Lysosomal Homeostasis in Macrophages and Promotes Systemic Inflammation in Mice

    Macrophages are professional phagocytes that are essential for host defense and tissue homeostasis. Proper membrane trafficking and degradative functions of the endolysosomal system are known to be critical for the function of these cells. We have found that PIKfyve, the kinase that synthesizes the endosomal phosphoinositide phosphatidylinositol-3,5-bisphosphate, is an essential regulator of lysosomal biogenesis and degradative...

    Sang Hee Min, Aae Suzuki, Lehn Weaver, Jessica Guzman, Yutein Chung, Huiyan Jin, Francina Gonzalez, Claire Trasorras, Liang Zhao, Lynn A. Spruce, Steven H. Seeholzer, Edward M. Behrens, Charles S. Abrams
  • Research Article | Spotlight
    Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor 1 Shed by ADAM17 Drives Mouse Macrophage Proliferation in Acute and Chronic Inflammation

    Macrophages are prominent cells in acute and chronic inflammatory diseases. Recent studies highlight a role for macrophage proliferation post-monocyte recruitment under inflammatory conditions.

    Jingjing Tang, Jeremy M. Frey, Carole L. Wilson, Angela Moncada-Pazos, Clémence Levet, Matthew Freeman, Michael E. Rosenfeld, E. Richard Stanley, Elaine W. Raines, Karin E. Bornfeldt
  • Research Article | Spotlight
    Liver X Receptor Nuclear Receptors Are Transcriptional Regulators of Dendritic Cell Chemotaxis
    Susana Beceiro, Attila Pap, Zsolt Czimmerer, Tamer Sallam, Jose A. Guillén, Germán Gallardo, Cynthia Hong, Noelia A-Gonzalez, Carlos Tabraue, Mercedes Diaz, Felix Lopez, Jonathan Matalonga, Annabel F. Valledor, Pilar Dominguez, Carlos Ardavin, Cristina Delgado-Martin, Santiago Partida-Sanchez, Jose Luis Rodriguez-Fernandez, Laszlo Nagy, Peter Tontonoz, Antonio Castrillo
  • Open Access
    Research Article
    Gain-of-Function Mutation of Tristetraprolin Impairs Negative Feedback Control of Macrophages In Vitro yet Has Overwhelmingly Anti-Inflammatory Consequences In Vivo
    John D. O'Neil, Ewan A. Ross, Michael L. Ridley, Qize Ding, Tina Tang, Dalya R. Rosner, Thomas Crowley, Deepak Malhi, Jonathan L. Dean, Tim Smallie, Christopher D. Buckley, Andrew R. Clark
  • Research Article
    FABP4/aP2 Regulates Macrophage Redox Signaling and Inflammasome Activation via Control of UCP2
    Kaylee A. Steen, Hongliang Xu, David A. Bernlohr
  • Open Access
    Research Article
    Beta Interferon Production Is Regulated by p38 Mitogen-Activated Protein Kinase in Macrophages via both MSK1/2- and Tristetraprolin-Dependent Pathways
    Victoria A. McGuire, Dalya Rosner, Olga Ananieva, Ewan A. Ross, Suzanne E. Elcombe, Shaista Naqvi, Mirjam M. W. van den Bosch, Claire E. Monk, Tamara Ruiz-Zorrilla Diez, Andrew R. Clark, J. Simon C. Arthur
  • Research Article | Spotlight
    PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages
    Annemarie Guentsch, Angelika Beneke, Lija Swain, Katja Farhat, Shunmugam Nagarajan, Ben Wielockx, Kaamini Raithatha, Jan Dudek, Peter Rehling, Anke Zieseniss, Aline Jatho, Mei Chong, Celio X. C. Santos, Ajay M. Shah, Dörthe M. Katschinski
  • Articles
    Forkhead Box M1 Transcription Factor Is Required for Macrophage Recruitment during Liver Repair
    Xiaomeng Ren, Yufang Zhang, Jonathan Snyder, Emily R. Cross, Tushar A. Shah, Tanya V. Kalin, Vladimir V. Kalinichenko

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