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  • Analysis of 1,25-Dihydroxyvitamin D<sub>3</sub> Genomic Action Reveals Calcium-Regulating and Calcium-Independent Effects in Mouse Intestine and Human Enteroids
    Research Article
    Analysis of 1,25-Dihydroxyvitamin D3 Genomic Action Reveals Calcium-Regulating and Calcium-Independent Effects in Mouse Intestine and Human Enteroids

    Although vitamin D is critical for the function of the intestine, most studies have focused on the duodenum. We show that transgenic expression of the vitamin D receptor (VDR) only in the distal intestine of VDR null mice (KO/TG mice) results in the normalization of serum calcium and rescue of rickets. Although it had been suggested that calcium transport in the distal intestine involves a paracellular process, we found that the 1,25-...

    Shanshan Li, Jessica De La Cruz, Steven Hutchens, Somshuvra Mukhopadhyay, Zachary K. Criss, Rohit Aita, Oscar Pellon-Cardenas, Joseph Hur, Patricia Soteropoulos, Seema Husain, Puneet Dhawan, Lieve Verlinden, Geert Carmeliet, James C. Fleet, Noah F. Shroyer, Michael P. Verzi, Sylvia Christakos
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