metabolism
Research Article | SpotlightSirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle ControlThe ubiquitin-proteasome system is essential for cell cycle progression. Cyclin F is a cell cycle-regulated substrate adapter F-box protein for the Skp1, CUL1, and F-box protein (SCF) family of E3 ubiquitin ligases.
Research Article | SpotlightThe Role of Metabolic Flexibility in the Regulation of the DNA Damage Response by Nitric OxideIn this report, we show that nitric oxide suppresses DNA damage response (DDR) signaling in the pancreatic β-cell line INS 832/13 and rat islets by inhibiting intermediary metabolism. Nitric oxide is known to inhibit complex IV of the electron transport chain and aconitase of the Krebs cycle.
- Research Article | SpotlightA Complex Relationship between Immunity and Metabolism in Drosophila Diet-Induced Insulin Resistance