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metabolism

  • Sirtuin 5 Is Regulated by the SCF<sup>Cyclin F</sup> Ubiquitin Ligase and Is Involved in Cell Cycle Control
    Research Article | Spotlight
    Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control

    The ubiquitin-proteasome system is essential for cell cycle progression. Cyclin F is a cell cycle-regulated substrate adapter F-box protein for the Skp1, CUL1, and F-box protein (SCF) family of E3 ubiquitin ligases.

    Christine A. Mills, Xianxi Wang, Dhaval P. Bhatt, Paul A. Grimsrud, Jacob Peter Matson, Debojyoti Lahiri, Daniel J. Burke, Jeanette Gowen Cook, Matthew D. Hirschey, Michael J. Emanuele
  • The Role of Metabolic Flexibility in the Regulation of the DNA Damage Response by Nitric Oxide
    Research Article | Spotlight
    The Role of Metabolic Flexibility in the Regulation of the DNA Damage Response by Nitric Oxide

    In this report, we show that nitric oxide suppresses DNA damage response (DDR) signaling in the pancreatic β-cell line INS 832/13 and rat islets by inhibiting intermediary metabolism. Nitric oxide is known to inhibit complex IV of the electron transport chain and aconitase of the Krebs cycle.

    Bryndon J. Oleson, Katarzyna A. Broniowska, Chay Teng Yeo, Michael Flancher, Aaron Naatz, Neil Hogg, Vera L. Tarakanova, John A. Corbett
  • Research Article | Spotlight
    A Complex Relationship between Immunity and Metabolism in Drosophila Diet-Induced Insulin Resistance
    Laura Palanker Musselman, Jill L. Fink, Ana R. Grant, Jared A. Gatto, Bryon F. Tuthill, Thomas J. Baranski
  • Research Article
    Effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism
    Matilda Eriksson, Gorbatchev Ambroise, Amanda Tomie Ouchida, Andre Lima Queiroz, Dominique Smith, Alfredo Gimenez-Cassina, Marcin P. Iwanicki, Patricia A. Muller, Erik Norberg, Helin Vakifahmetoglu-Norberg
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