methylation
Research ArticleDynamic Methylation of an L1 Transduction Family during Reprogramming and NeurodifferentiationThe retrotransposon LINE-1 (L1) is a significant source of endogenous mutagenesis in humans. In each individual genome, a few retrotransposition-competent L1s (RC-L1s) can generate new heritable L1 insertions in the early embryo, primordial germ line, and germ cells.
- TRANSCRIPTIONAL REGULATIONMethylation of Adjacent CpG Sites Affects Sp1/Sp3 Binding and Activity in the p21Cip1 Promoter