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mitosis

  • The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch
    Research Article | Spotlight
    The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch

    PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1) is a tumor suppressor that directly dephosphorylates a wide array of substrates, most notably the prosurvival kinase Akt. However, little is known about the molecular mechanisms governing PHLPP1 itself.

    Agnieszka T. Kawashima, Cassandra Wong, Gema Lordén, Charles C. King, Pablo Lara-Gonzalez, Arshad Desai, Anne-Claude Gingras, Alexandra C. Newton
  • A Fresh Look at the Structure, Regulation, and Functions of Fodrin
    Minireview
    A Fresh Look at the Structure, Regulation, and Functions of Fodrin

    Fodrin and its erythroid cell-specific isoform spectrin are actin-associated fibrous proteins that play crucial roles in the maintenance of structural integrity in mammalian cells, which is necessary for proper cell function. Normal cell morphology is altered in diseases such as various cancers and certain neuronal disorders. Fodrin and spectrin are two-chain (αβ) molecules that are encoded by paralogous genes and share many features...

    Jamuna S. Sreeja, Rince John, Dhrishya Dharmapal, Rohith Kumar Nellikka, Suparna Sengupta
  • Open Access
    Nocodazole-Induced Expression and Phosphorylation of Anillin and Other Mitotic Proteins Are Decreased in DNA-Dependent Protein Kinase Catalytic Subunit-Deficient Cells and Rescued by Inhibition of the Anaphase-Promoting Complex/Cyclosome with proTAME but Not Apcin
    Research Article
    Nocodazole-Induced Expression and Phosphorylation of Anillin and Other Mitotic Proteins Are Decreased in DNA-Dependent Protein Kinase Catalytic Subunit-Deficient Cells and Rescued by Inhibition of the Anaphase-Promoting Complex/Cyclosome with proTAME but Not Apcin

    The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has well-established roles in DNA double-strand break repair, and recently, nonrepair functions have also been reported. To better understand its cellular functions, we deleted DNA-PKcs from HeLa and A549 cells using CRISPR/Cas9. The resulting cells were radiation sensitive, had reduced expression of ataxia-telangiectasia mutated (ATM), and exhibited multiple mitotic defects...

    Pauline Douglas, Ruiqiong Ye, Suraj Radhamani, Alexander Cobban, Nicole P. Jenkins, Edward Bartlett, Jonathan Roveredo, Arminja N. Kettenbach, Susan P. Lees-Miller
  • AKT Regulates Mitotic Progression of Mammalian Cells by Phosphorylating MASTL, Leading to Protein Phosphatase 2A Inactivation
    Research Article
    AKT Regulates Mitotic Progression of Mammalian Cells by Phosphorylating MASTL, Leading to Protein Phosphatase 2A Inactivation

    Microtubule-associated serine/threonine kinase like (MASTL), also known as Greatwall (Gwl) kinase, has an important role in the regulation of mitosis. By inhibiting protein phosphatase 2A (PP2A), it plays a crucial role in activating one of the most important mitotic kinases, known as cyclin-dependent kinase 1 (CDK1). MASTL has been seen to be upregulated in various types of cancers and is also involved in tumor recurrence. It is...

    Irfana Reshi, Misbah Un Nisa, Umer Farooq, Syed Qaaifah Gillani, Sameer Ahmed Bhat, Zarka Sarwar, Nusrat Nabi, Khalid Majid Fazili, Shaida Andrabi
  • <em>RB1</em> Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression
    Research Article
    RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression

    Proliferative control in cancer cells is frequently disrupted by mutations in the retinoblastoma protein (RB) pathway. Intriguingly, RB1 mutations can arise late in tumorigenesis in cancer cells whose RB pathway is already compromised by another mutation. In this study, we present evidence for increased DNA damage and instability in cancer cells with RB pathway defects when RB1 mutations are induced.

    ...
    Aren E. Marshall, Michael V. Roes, Daniel T. Passos, Megan C. DeWeerd, Andrea C. Chaikovsky, Julien Sage, Christopher J. Howlett, Frederick A. Dick
  • Minireview
    Centromere Biology: Transcription Goes on Stage

    Accurate chromosome segregation is a fundamental process in cell biology. During mitosis, chromosomes are segregated into daughter cells through interactions between centromeres and microtubules in the mitotic spindle.

    Carlos Perea-Resa, Michael D. Blower
  • Research Article
    Asp1 Bifunctional Activity Modulates Spindle Function via Controlling Cellular Inositol Pyrophosphate Levels in Schizosaccharomyces pombe
    Marina Pascual-Ortiz, Adolfo Saiardi, Eva Walla, Visnja Jakopec, Natascha A. Künzel, Ingrid Span, Anand Vangala, Ursula Fleig
  • Research Article
    DNA Damage Response-Independent Role for MDC1 in Maintaining Genomic Stability
    Zhiguo Li, Chen Shao, Yifan Kong, Colin Carlock, Nihal Ahmad, Xiaoqi Liu
  • Open Access
    Research Article
    INPP5E Preserves Genomic Stability through Regulation of Mitosis
    Elizabeth A. Sierra Potchanant, Donna Cerabona, Zahi Abdul Sater, Ying He, Zejin Sun, Jeff Gehlhausen, Grzegorz Nalepa
  • Articles
    Symplekin Specifies Mitotic Fidelity by Supporting Microtubule Dynamics
    Kathryn M. Cappell, Brittany Larson, Noah Sciaky, Angelique W. Whitehurst

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