NRF3

  • NFE2L1 and NFE2L3 Complementarily Maintain Basal Proteasome Activity in Cancer Cells through CPEB3-Mediated Translational Repression
    Research Article
    NFE2L1 and NFE2L3 Complementarily Maintain Basal Proteasome Activity in Cancer Cells through CPEB3-Mediated Translational Repression

    Proteasomes are protease complexes essential for cellular homeostasis, and their activity is crucial for cancer cell growth. However, the mechanism of how proteasome activity is maintained in cancer cells has remained unclear. The CNC family transcription factor NFE2L1 induces the expression of almost all proteasome-related genes under proteasome inhibition. Both NFE2L1 and its phylogenetically closest homolog, NFE2L3...

    Tsuyoshi Waku, Hiroyuki Katayama, Miyako Hiraoka, Atsushi Hatanaka, Nanami Nakamura, Yuya Tanaka, Natsuko Tamura, Akira Watanabe, Akira Kobayashi
  • Open Access
    NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein
    Research Article | Spotlight
    NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein

    Proteasomes are essential protease complexes that maintain cellular homeostasis, and aberrant proteasomal activity supports cancer development. The regulatory mechanisms and biological function of the ubiquitin-26S proteasome have been studied extensively, while those of the ubiquitin-independent 20S proteasome system remain obscure. Here, we show that the cap ’n’ collar (CNC) family transcription factor NRF3 specifically enhances 20S...

    Tsuyoshi Waku, Nanami Nakamura, Misaki Koji, Hidenori Watanabe, Hiroki Katoh, Chika Tatsumi, Natsuko Tamura, Atsushi Hatanaka, Shuuhei Hirose, Hiroyuki Katayama, Misato Tani, Yuki Kubo, Jun Hamazaki, Takao Hamakubo, Akira Watanabe, Shigeo Murata, Akira Kobayashi
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