nuclear receptor
Research Article | SpotlightInflammation Triggers Liver X Receptor-Dependent LipogenesisImmune cell function can be modulated by changes in lipid metabolism. Our studies indicate that cholesterol and fatty acid synthesis increases in macrophages between 12 and 18 h after the activation of Toll-like receptors with proinflammatory stimuli and that the upregulation of lipogenesis may contribute to the resolution of inflammation.
Research Article | SpotlightLoss of Estrogen-Related Receptor Alpha Facilitates Angiogenesis in Endothelial CellsEstrogen-related receptors (ERRs) have emerged as major metabolic regulators in various tissues. However, their expression and function in the vasculature remains unknown.
Research ArticleCommon and Differential Transcriptional Actions of Nuclear Receptors Liver X Receptors α and β in MacrophagesThe liver X receptors α and β (LXRα and LXRβ) are oxysterol-activated transcription factors that coordinately regulate gene expression that is important for cholesterol and fatty acid metabolism. In addition to their roles in lipid metabolism, LXRs participate in the transcriptional regulation of macrophage activation and are considered potent regulators of inflammation.