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nuclear receptor

  • Inflammation Triggers Liver X Receptor-Dependent Lipogenesis
    Research Article | Spotlight
    Inflammation Triggers Liver X Receptor-Dependent Lipogenesis

    Immune cell function can be modulated by changes in lipid metabolism. Our studies indicate that cholesterol and fatty acid synthesis increases in macrophages between 12 and 18 h after the activation of Toll-like receptors with proinflammatory stimuli and that the upregulation of lipogenesis may contribute to the resolution of inflammation.

    Sophie R. Liebergall, Jerry Angdisen, Shun Hang Chan, YingJu Chang, Timothy F. Osborne, Alexander F. Koeppel, Stephen D. Turner, Ira G. Schulman
  • Loss of Estrogen-Related Receptor Alpha Facilitates Angiogenesis in Endothelial Cells
    Research Article | Spotlight
    Loss of Estrogen-Related Receptor Alpha Facilitates Angiogenesis in Endothelial Cells

    Estrogen-related receptors (ERRs) have emerged as major metabolic regulators in various tissues. However, their expression and function in the vasculature remains unknown.

    Neah Likhite, Vikas Yadav, Eric J. Milliman, Danesh H. Sopariwala, Sabina Lorca, Nithya P. Narayana, Megha Sheth, Erin L. Reineke, Vincent Giguère, Vihang Narkar
  • Common and Differential Transcriptional Actions of Nuclear Receptors Liver X Receptors α and β in Macrophages
    Research Article
    Common and Differential Transcriptional Actions of Nuclear Receptors Liver X Receptors α and β in Macrophages

    The liver X receptors α and β (LXRα and LXRβ) are oxysterol-activated transcription factors that coordinately regulate gene expression that is important for cholesterol and fatty acid metabolism. In addition to their roles in lipid metabolism, LXRs participate in the transcriptional regulation of macrophage activation and are considered potent regulators of inflammation.

    Ana Ramón-Vázquez, Juan Vladimir de la Rosa, Carlos Tabraue, Felix Lopez, Bonifacio Nicolas Díaz-Chico, Lisardo Bosca, Peter Tontonoz, Susana Alemany, Antonio Castrillo
  • Research Article
    CREBH Maintains Circadian Glucose Homeostasis by Regulating Hepatic Glycogenolysis and Gluconeogenesis
    Hyunbae Kim, Ze Zheng, Paul D. Walker, Gregory Kapatos, Kezhong Zhang
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