p53
Research Article | SpotlightNRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma ProteinProteasomes are essential protease complexes that maintain cellular homeostasis, and aberrant proteasomal activity supports cancer development. The regulatory mechanisms and biological function of the ubiquitin-26S proteasome have been studied extensively, while those of the ubiquitin-independent 20S proteasome system remain obscure. Here, we show that the cap ’n’ collar (CNC) family transcription factor NRF3 specifically enhances 20S...
Research Article | SpotlightA Circular RNA from the MDM2 Locus Controls Cell Cycle Progression by Suppressing p53 LevelsCircular RNAs (circRNAs) are a class of noncoding RNAs produced by a noncanonical form of alternative splicing called back-splicing. To investigate a potential role of circRNAs in the p53 pathway, we analyzed RNA sequencing (RNA-seq) data from colorectal cancer cell lines (HCT116, RKO, and SW48) that were untreated or treated with a DNA-damaging agent. Surprisingly, unlike the strong p53-dependent induction of hundreds of p53-induced...
Research ArticleNOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative AgingThe nucleolus is a subnuclear compartment with key roles in rRNA synthesis and ribosome biogenesis, complex processes that require hundreds of proteins and factors. Alterations in nucleolar morphology and protein content have been linked to the control of cell proliferation and stress responses and, recently, further implicated in cell senescence and ageing.
- Research Article | SpotlightEvidence of a Prion-Like Transmission of p53 Amyloid in Saccharomyces cerevisiae
- Research Article | Spotlightp53 Dynamically Directs TFIID Assembly on Target Gene Promoters