Proto-Oncogenes

MAMMALIAN GENETIC MODELS WITH MINIMAL OR COMPLEX PHENOTYPES
Infertility with Defective Spermiogenesis in Mice Lacking AF5q31, the Target of Chromosomal Translocation in Human Infant Leukemia
Atsushi Urano, Masaki Endoh, Tadashi Wada, Yoshihiro Morikawa, Miyuki Itoh, Yuki Kataoka, Tomohiko Taki, Hiroshi Akazawa, Hideaki Nakajima, Issei Komuro, Nobuaki Yoshida, Yasuhide Hayashi, Hiroshi Handa, Toshio Kitamura, Tetsuya Nosaka
CELL GROWTH AND DEVELOPMENT
Binding to Nonmethylated CpG DNA Is Essential for Target Recognition, Transactivation, and Myeloid Transformation by an MLL Oncoprotein
Paul M. Ayton, Everett H. Chen, Michael L. Cleary
TRANSCRIPTIONAL REGULATION
Leukemia Proto-Oncoprotein MLL Forms a SET1-Like Histone Methyltransferase Complex with Menin To Regulate Hox Gene Expression
Akihiko Yokoyama, Zhong Wang, Joanna Wysocka, Mrinmoy Sanyal, Deborah J. Aufiero, Issay Kitabayashi, Winship Herr, Michael L. Cleary
TRANSCRIPTIONAL REGULATION
Novel SWI/SNF Chromatin-Remodeling Complexes Contain a Mixed-Lineage Leukemia Chromosomal Translocation Partner
Zuqin Nie, Zhijiang Yan, Everett H. Chen, Salvatore Sechi, Chen Ling, Sharleen Zhou, Yutong Xue, Dafeng Yang, Darryl Murray, Emi Kanakubo, Michael L. Cleary, Weidong Wang
TRANSCRIPTIONAL REGULATION
The Leucine Zipper Motif of the Drosophila AF10 Homologue Can Inhibit PRE-Mediated Repression: Implications for Leukemogenic Activity of Human MLL-AF10 Fusions
Laurent Perrin, Sébastien Bloyer, Conchita Ferraz, Namita Agrawal, Pradip Sinha, Jean Maurice Dura
GENE EXPRESSION
Proteolytic Cleavage of MLL Generates a Complex of N- and C-Terminal Fragments That Confers Protein Stability and Subnuclear Localization
James J.-D. Hsieh, Patricia Ernst, Hediye Erdjument-Bromage, Paul Tempst, Stanley J. Korsmeyer
CELL GROWTH AND DEVELOPMENT
Mouse Af9 Is a Controller of Embryo Patterning, Like Mll, Whose Human Homologue Fuses with AF9 after Chromosomal Translocation in Leukemia
Emma C. Collins, Alexandre Appert, Linda Ariza-McNaughton, Richard Pannell, Yoshihiro Yamada, Terence H. Rabbitts
TRANSCRIPTIONAL REGULATION
MLL-AFX Requires the Transcriptional Effector Domains of AFX To Transform Myeloid Progenitors and Transdominantly Interfere with Forkhead Protein Function
Chi Wai So, Michael L. Cleary
CELL GROWTH AND DEVELOPMENT
The Elongation Domain of ELL Is Dispensable but Its ELL-Associated Factor 1 Interaction Domain Is Essential for MLL-ELL-Induced Leukemogenesis
Roger T. Luo, Catherine Lavau, Changchun Du, Federico Simone, Paul E. Polak, Shin Kawamata, Michael J. Thirman
TRANSCRIPTIONAL REGULATION
Protein Interactions of the MLL PHD Fingers Modulate MLL Target Gene Regulation in Human Cells
Keri Fair, Melanie Anderson, Elena Bulanova, Huaifeng Mi, Maximilian Tropschug, Manuel O. Diaz

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Proto-Oncogenes

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