Ras
MinireviewA Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function PerspectiveSHOC2 is a prototypical leucine-rich repeat protein that promotes downstream receptor tyrosine kinase (RTK)/RAS signaling and plays important roles in several cellular and developmental processes. Gain-of-function germ line mutations of SHOC2 drive the RASopathy Noonan-like syndrome, and SHOC2 mediates adaptive resistance to mitogen-activated protein kinase (MAPK) inhibitors.
- Research Article | SpotlightPhosphorylation of the C-Raf N Region Promotes Raf Dimerization