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shelterin

  • Open Access
    TIN2 Functions with TPP1/POT1 To Stimulate Telomerase Processivity
    Research Article | Spotlight
    TIN2 Functions with TPP1/POT1 To Stimulate Telomerase Processivity

    TIN2 is an important regulator of telomere length, and mutations in TINF2, the gene encoding TIN2, cause short-telomere syndromes. While the genetics underscore the importance of TIN2, the mechanism through which TIN2 regulates telomere length remains unclear. Here, we tested the effects of human TIN2 on telomerase activity. We identified a new isoform in human cells, TIN2M, that is expressed at levels similar to those of...

    Alexandra M. Pike, Margaret A. Strong, John Paul T. Ouyang, Carol W. Greider
  • Open Access
    Research Article
    The C-Terminal Extension Unique to the Long Isoform of the Shelterin Component TIN2 Enhances Its Interaction with TRF2 in a Phosphorylation- and Dyskeratosis Congenita Cluster-Dependent Fashion
    Nya D. Nelson, Lois M. Dodson, Laura Escudero, Ann T. Sukumar, Christopher L. Williams, Ivana Mihalek, Alessandro Baldan, Duncan M. Baird, Alison A. Bertuch
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