Sox9
Research ArticleRole of SMPD3 during Bone Fracture Healing and Regulation of Its ExpressionSphingomyelin phosphodiesterase 3 (SMPD3), a lipid-metabolizing enzyme present in bone and cartilage, has important roles in the developing skeleton. We previously showed that SMPD3 deficiency results in delayed extracellular matrix (ECM) mineralization and severe skeletal deformities in an inducible knockout mouse model, Smpd3flox/flox; Osx-Cre mice, in which Smpd3 was ablated in Osx-...