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STAT3

  • Interleukin-8 Dedifferentiates Primary Human Luminal Cells to Multipotent Stem Cells
    Research Article
    Interleukin-8 Dedifferentiates Primary Human Luminal Cells to Multipotent Stem Cells

    During aging, cellular plasticity and senescence play important roles in tissue regeneration and the pathogenesis of different diseases, including cancer. We have recently shown that senescent breast luminal cells can activate their adjacent stromal fibroblasts. In the present report, we present clear evidence that these senescence-related active fibroblasts can dedifferentiate proliferating primary human luminal cells to multipotent...

    Huda H. Al-Khalaf, Hazem Ghebeh, Salma M. Wakil, Falah Al-Mohanna, Abdelilah Aboussekhra
  • Interleukin-8 Activates Breast Cancer-Associated Adipocytes and Promotes Their Angiogenesis- and Tumorigenesis-Promoting Effects
    Research Article
    Interleukin-8 Activates Breast Cancer-Associated Adipocytes and Promotes Their Angiogenesis- and Tumorigenesis-Promoting Effects

    Increasing evidence supports the critical role of active stromal adipocytes in breast cancer development and spread. However, the mediators and the mechanisms of action are still elusive.

    Huda H. Al-Khalaf, Bothaina Al-Harbi, Adher Al-Sayed, Maria Arafah, Asma Tulbah, Abdulaziz Jarman, Falah Al-Mohanna, Abdelilah Aboussekhra
  • Myc-Associated Zinc Finger Protein Regulates the Proinflammatory Response in Colitis and Colon Cancer via STAT3 Signaling
    Research Article
    Myc-Associated Zinc Finger Protein Regulates the Proinflammatory Response in Colitis and Colon Cancer via STAT3 Signaling

    Myc-associated zinc finger (MAZ) is a transcription factor highly upregulated in chronic inflammatory disease and several human cancers. In the present study, we found that MAZ protein is highly expressed in human ulcerative colitis and colon cancer.

    Daniel Triner, Cristina Castillo, Joe B. Hakim, Xiang Xue, Joel K. Greenson, Gabriel Nuñez, Grace Y. Chen, Justin A. Colacino, Yatrik M. Shah
  • Research Article
    SUMO Modification of the RNA-Binding Protein La Regulates Cell Proliferation and STAT3 Protein Stability
    Venkatesh Kota, Gunhild Sommer, E. Starr Hazard, Gary Hardiman, Jeffery L. Twiss, Tilman Heise
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