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stem cells

  • Interleukin-8 Dedifferentiates Primary Human Luminal Cells to Multipotent Stem Cells
    Research Article
    Interleukin-8 Dedifferentiates Primary Human Luminal Cells to Multipotent Stem Cells

    During aging, cellular plasticity and senescence play important roles in tissue regeneration and the pathogenesis of different diseases, including cancer. We have recently shown that senescent breast luminal cells can activate their adjacent stromal fibroblasts. In the present report, we present clear evidence that these senescence-related active fibroblasts can dedifferentiate proliferating primary human luminal cells to multipotent...

    Huda H. Al-Khalaf, Hazem Ghebeh, Salma M. Wakil, Falah Al-Mohanna, Abdelilah Aboussekhra
  • Reactive Oxygen Species Signaling Promotes Hypoxia-Inducible Factor 1α Stabilization in Sonic Hedgehog-Driven Cerebellar Progenitor Cell Proliferation
    Research Article
    Reactive Oxygen Species Signaling Promotes Hypoxia-Inducible Factor 1α Stabilization in Sonic Hedgehog-Driven Cerebellar Progenitor Cell Proliferation

    Cerebellar development is a highly regulated process involving numerous factors acting with high specificity, both temporally and by location. Part of this process involves extensive proliferation of cerebellar granule neuron precursors (CGNPs) induced by Sonic Hedgehog (SHH) signaling, but downstream effectors of mitogenic signaling are still being elucidated.

    Nicholas W. Eyrich, Chad R. Potts, M. Hope Robinson, Victor Maximov, Anna M. Kenney
  • Open Access
    Research Article
    MicroRNA 33 Regulates the Population of Peripheral Inflammatory Ly6Chigh Monocytes through Dual Pathways
    Osamu Baba, Takahiro Horie, Tetsushi Nakao, Daihiko Hakuno, Yasuhiro Nakashima, Hitoo Nishi, Yasuhide Kuwabara, Masataka Nishiga, Tomohiro Nishino, Yuya Ide, Fumiko Nakazeki, Satoshi Koyama, Masahiro Kimura, Ritsuko Hanada, Masahiro Kawahara, Takeshi Kimura, Koh Ono
  • Minireview
    FOXN1 Transcription Factor in Epithelial Growth and Wound Healing
    Anna I. Grabowska, Tomasz Wilanowski
  • Open Access
    Research Article | Spotlight
    Arginine Methylation by PRMT1 Regulates Muscle Stem Cell Fate
    Roméo Sébastien Blanc, Gillian Vogel, Xing Li, Zhenbao Yu, Shawn Li, Stéphane Richard
  • Articles
    Runx1 Directly Promotes Proliferation of Hair Follicle Stem Cells and Epithelial Tumor Formation in Mouse Skin
    Charlene S. L. Hoi, Song Eun Lee, Shu-Yang Lu, David J. McDermitt, Karen M. Osorio, Caroline M. Piskun, Rachel M. Peters, Ralf Paus, Tudorita Tumbar
  • Articles
    The TAL1/SCL Transcription Factor Regulates Cell Cycle Progression and Proliferation in Differentiating Murine Bone Marrow Monocyte Precursors
    Soumyadeep Dey, David J. Curtis, Stephen M. Jane, Stephen J. Brandt
  • Articles
    Histone Demethylase LSD1 Regulates Neural Stem Cell Proliferation
    GuoQiang Sun, Kamil Alzayady, Richard Stewart, Peng Ye, Su Yang, Wendong Li, Yanhong Shi
  • Articles
    The p107/E2F Pathway Regulates Fibroblast Growth Factor 2 Responsiveness in Neural Precursor Cells
    Kelly A. McClellan, Jacqueline L. Vanderluit, Lisa M. Julian, Matthew G. Andrusiak, Delphie Dugal-Tessier, David S. Park, Ruth S. Slack
  • Articles
    Trophoblast Stem Cell Maintenance by Fibroblast Growth Factor 4 Requires MEKK4 Activation of Jun N-Terminal Kinase
    Amy N. Abell, Deborah A. Granger, Nancy L. Johnson, Nicole Vincent-Jordan, Christopher F. Dibble, Gary L. Johnson

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