Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About MCB
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
Molecular and Cellular Biology
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About MCB
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions

transcription

  • Proteasomal Regulation of Mammalian SPT16 in Controlling Transcription
    Research Article
    Proteasomal Regulation of Mammalian SPT16 in Controlling Transcription

    FACT (facilitates chromatin transcription), an essential and evolutionarily conserved heterodimer from yeast to humans, controls transcription and is found to be upregulated in various cancers. However, the basis for such upregulation is not clearly understood.

    Amala Kaja, Abhinav Adhikari, Saswati Karmakar, Wanwei Zhang, Gerson Rothschild, Uttiya Basu, Surinder K. Batra, Judith K. Davie, Sukesh R. Bhaumik
  • Identification of Dominant Transcripts in Oxidative Stress Response by a Full-Length Transcriptome Analysis
    Research Article
    Identification of Dominant Transcripts in Oxidative Stress Response by a Full-Length Transcriptome Analysis

    Our body responds to environmental stress by changing the expression levels of a series of cytoprotective enzymes/proteins through multilayered regulatory mechanisms, including the KEAP1-NRF2 system. While NRF2 upregulates the expression of many cytoprotective genes, there are fundamental limitations in short-read RNA sequencing (RNA-Seq), resulting in confusion regarding interpreting the effectiveness of cytoprotective gene induction...

    Akihito Otsuki, Yasunobu Okamura, Yuichi Aoki, Noriko Ishida, Kazuki Kumada, Naoko Minegishi, Fumiki Katsuoka, Kengo Kinoshita, Masayuki Yamamoto
  • Molecular Topology of RNA Polymerase I Upstream Activation Factor
    Research Article | Spotlight
    Molecular Topology of RNA Polymerase I Upstream Activation Factor

    Upstream activation factor (UAF) is a multifunctional transcription factor in Saccharomyces cerevisiae that plays dual roles in activating RNA polymerase I (Pol I) transcription and repression of Pol II. For Pol I, UAF binds to a specific upstream element in the ribosomal DNA (rDNA) promoter and interacts with two other Pol I initiation factors, the TATA-binding...

    Bruce A. Knutson, Marissa L. Smith, Alana E. Belkevich, Aula M. Fakhouri
  • Mutual Balance of Histone Deacetylases 1 and 2 and the Acetyl Reader ATAD2 Regulates the Level of Acetylation of Histone H4 on Nascent Chromatin of Human Cells
    Research Article | Spotlight
    Mutual Balance of Histone Deacetylases 1 and 2 and the Acetyl Reader ATAD2 Regulates the Level of Acetylation of Histone H4 on Nascent Chromatin of Human Cells

    Newly synthesized histone H4 that is incorporated into chromatin during DNA replication is acetylated on lysines 5 and 12. Histone deacetylase 1 (HDAC1) and HDAC2 are responsible for reducing H4 acetylation as chromatin matures. Using CRISPR-Cas9-generated hdac1- or hdac2-null fibroblasts, we determined that HDAC1 and HDAC2 do not fully compensate for each other in removing de novo acetyls on H4 in vivo...

    Pavlo Lazarchuk, John Hernandez-Villanueva, Maria N. Pavlova, Alexander Federation, Michael MacCoss, Julia M. Sidorova
  • MicroRNA 27a Is a Key Modulator of Cholesterol Biosynthesis
    Research Article
    MicroRNA 27a Is a Key Modulator of Cholesterol Biosynthesis

    Hypercholesterolemia is a strong predictor of cardiovascular diseases. The 3-hydroxy-3-methylglutaryl coenzyme A reductase gene (Hmgcr) coding for the rate-limiting enzyme in the cholesterol biosynthesis pathway is a crucial regulator of plasma cholesterol levels. However, the posttranscriptional regulation of Hmgcr remains poorly understood. The main objective of this study was to explore the role of microRNAs (miRNAs) in the...

    Abrar A. Khan, Heena Agarwal, S. Santosh Reddy, Vikas Arige, Bhargavi Natarajan, Vinayak Gupta, Ananthamohan Kalyani, Manoj K. Barthwal, Nitish R. Mahapatra
  • ZFP628 Is a TAF4b-Interacting Transcription Factor Required for Mouse Spermiogenesis
    Research Article | Spotlight
    ZFP628 Is a TAF4b-Interacting Transcription Factor Required for Mouse Spermiogenesis

    TAF4b is a subunit of the TFIID complex that is highly expressed in the ovary and testis and required for mouse fertility. TAF4b-deficient male mice undergo a complex series of developmental defects that result in the inability to maintain long-term spermatogenesis. To decipher the transcriptional mechanisms upon which TAF4b functions in spermatogenesis, we used two-hybrid screening to identify a novel TAF4b-interacting transcriptional...

    Eric A. Gustafson, Kimberly A. Seymour, Kirsten Sigrist, Dirk G. D. E. Rooij, Richard N. Freiman
  • An F-Box Protein, Mdm30, Interacts with TREX Subunit Sub2 To Regulate Cellular Abundance Cotranscriptionally in Orchestrating mRNA Export Independently of Splicing and Mitochondrial Function
    Research Article
    An F-Box Protein, Mdm30, Interacts with TREX Subunit Sub2 To Regulate Cellular Abundance Cotranscriptionally in Orchestrating mRNA Export Independently of Splicing and Mitochondrial Function

    Although an F-box protein, Mdm30, is found to regulate ubiquitylation of the Sub2 component of TREX (transcription-export) complex for proteasomal degradation in stimulation of mRNA export, it remains unknown whether such ubiquitin-proteasome system (UPS) regulation of Sub2 occurs cotranscriptionally via its interaction with Mdm30. Further, it is unclear whether impaired UPS...

    Jannatul Ferdoush, Rwik Sen, Geetha Durairaj, Priyanka Barman, Amala Kaja, Shalini Guha, Sukesh R. Bhaumik
  • Inflammation Triggers Liver X Receptor-Dependent Lipogenesis
    Research Article | Spotlight
    Inflammation Triggers Liver X Receptor-Dependent Lipogenesis

    Immune cell function can be modulated by changes in lipid metabolism. Our studies indicate that cholesterol and fatty acid synthesis increases in macrophages between 12 and 18 h after the activation of Toll-like receptors with proinflammatory stimuli and that the upregulation of lipogenesis may contribute to the resolution of inflammation.

    Sophie R. Liebergall, Jerry Angdisen, Shun Hang Chan, YingJu Chang, Timothy F. Osborne, Alexander F. Koeppel, Stephen D. Turner, Ira G. Schulman
  • ZFP281 Recruits MYC to Active Promoters in Regulating Transcriptional Initiation and Elongation
    Research Article
    ZFP281 Recruits MYC to Active Promoters in Regulating Transcriptional Initiation and Elongation

    The roles of the MYC transcription factor in transcriptional regulation have been studied intensively. However, the general mechanism underlying the recruitment of MYC to chromatin is less clear. Here, we found that the Krüppel-like transcription factor ZFP281 plays important roles in recruiting MYC to active promoters in mouse embryonic stem cells.

    Zhuojuan Luo, Xiaoxu Liu, Hao Xie, Yan Wang, Chengqi Lin
  • Open Access
    Omomyc Reveals New Mechanisms To Inhibit the MYC Oncogene
    Research Article
    Omomyc Reveals New Mechanisms To Inhibit the MYC Oncogene

    The MYC oncogene is upregulated in human cancers by translocation, amplification, and mutation of cellular pathways that regulate Myc. Myc/Max heterodimers bind to E box sequences in the promoter regions of genes and activate transcription.

    Mark J. Demma, Claudio Mapelli, Angie Sun, Smaranda Bodea, Benjamin Ruprecht, Sarah Javaid, Derek Wiswell, Eric Muise, Shiying Chen, John Zelina, Federica Orvieto, Alessia Santoprete, Simona Altezza, Federica Tucci, Enrique Escandon, Brian Hall, Kallol Ray, Abbas Walji, Jennifer O’Neil

Pages

  • Next
  • 1
  • 2
  • 3
  • 4
Back to top

About

  • About MCB
  • Editor in Chief
  • Editorial Board
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Article Types
  • Ethics
  • Contact Us

Follow #MCBJournal

@ASMicrobiology

       

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 0270-7306; Online ISSN: 1098-5549