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transcriptional regulation

  • Tumor Necrosis Factor Alpha Regulates Skeletal Myogenesis by Inhibiting SP1 Interaction with <em>cis</em>-Acting Regulatory Elements within the Fbxl2 Gene Promoter
    Research Article
    Tumor Necrosis Factor Alpha Regulates Skeletal Myogenesis by Inhibiting SP1 Interaction with cis-Acting Regulatory Elements within the Fbxl2 Gene Promoter

    Skeletal muscle regeneration and repair involve the recruitment and proliferation of resident satellite cells that exit the cell cycle during the process of myogenic differentiation to form myofibers. We demonstrate that the ubiquitin E3 ligase subunit FBXL2 is essential for skeletal myogenesis through its important effects on cell cycle progression and cell proliferative signaling. Further, we characterize a new mechanism whereby...

    Michael E. O’Brien, James Londino, Marcus McGinnis, Nathaniel Weathington, Jessica Adair, Tomeka Suber, Valerian Kagan, Kong Chen, Chunbin Zou, Bill Chen, Jessica Bon, Rama K. Mallampalli
  • Inflammation Triggers Liver X Receptor-Dependent Lipogenesis
    Research Article | Spotlight
    Inflammation Triggers Liver X Receptor-Dependent Lipogenesis

    Immune cell function can be modulated by changes in lipid metabolism. Our studies indicate that cholesterol and fatty acid synthesis increases in macrophages between 12 and 18 h after the activation of Toll-like receptors with proinflammatory stimuli and that the upregulation of lipogenesis may contribute to the resolution of inflammation.

    Sophie R. Liebergall, Jerry Angdisen, Shun Hang Chan, YingJu Chang, Timothy F. Osborne, Alexander F. Koeppel, Stephen D. Turner, Ira G. Schulman
  • Regional Gene Repression by DNA Double-Strand Breaks in G<sub>1</sub> Phase Cells
    Research Article
    Regional Gene Repression by DNA Double-Strand Breaks in G1 Phase Cells

    DNA damage responses (DDR) to double-strand breaks (DSBs) alter cellular transcription programs at the genome-wide level. Through processes that are less well understood, DSBs also alter transcriptional responses locally, which may be important for efficient DSB repair. Here, we developed an approach to elucidate the cis-acting responses to DSBs in G1 phase cells.

    Caitlin E. Purman, Patrick L. Collins, Sofia I. Porter, Ankita Saini, Harshath Gupta, Barry P. Sleckman, Eugene M. Oltz
  • GATA2 and PU.1 Collaborate To Activate the Expression of the Mouse <em>Ms4a2</em> Gene, Encoding FcεRIβ, through Distinct Mechanisms
    Research Article | Spotlight
    GATA2 and PU.1 Collaborate To Activate the Expression of the Mouse Ms4a2 Gene, Encoding FcεRIβ, through Distinct Mechanisms

    GATA factors GATA1 and GATA2 and ETS factor PU.1 are known to function antagonistically during hematopoietic development. In mouse mast cells, however, these factors are coexpressed and activate the expression of the Ms4a2 gene encoding the β chain of the high-affinity IgE receptor (FcεRI). The present study showed that these factors cooperatively regulate Ms4a2 gene expression through distinct mechanisms.

    ...
    Shin’ya Ohmori, Yasushi Ishijima, Suzuka Numata, Mai Takahashi, Masataka Sekita, Taichi Sato, Keisuke Chugun, Masayuki Yamamoto, Kinuko Ohneda
  • Transcriptional and Epigenomic Regulation of Adipogenesis
    Minireview
    Transcriptional and Epigenomic Regulation of Adipogenesis

    Understanding adipogenesis, the process of adipocyte development, may provide new ways to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated actions of lineage-determining transcription factors and epigenomic regulators.

    Ji-Eun Lee, Hannah Schmidt, Binbin Lai, Kai Ge
  • Open Access
    Transcriptional Suppression of CPI-17 Gene Expression in Vascular Smooth Muscle Cells by Tumor Necrosis Factor, Krüppel-Like Factor 4, and Sp1 Is Associated with Lipopolysaccharide-Induced Vascular Hypocontractility, Hypotension, and Mortality
    Research Article
    Transcriptional Suppression of CPI-17 Gene Expression in Vascular Smooth Muscle Cells by Tumor Necrosis Factor, Krüppel-Like Factor 4, and Sp1 Is Associated with Lipopolysaccharide-Induced Vascular Hypocontractility, Hypotension, and Mortality

    Vasodilatory shock in sepsis is caused by the failure of the vasculature to respond to vasopressors, which results in hypotension, multiorgan failure, and ultimately patient death. Recently, it was reported that CPI-17, a key player in the regulation of smooth muscle contraction, was downregulated by lipopolysaccharide (LPS) in mesenteric arteries concordant with vascular hypocontractilty.

    Guogang Zhao, Yu Zhong, Wen Su, Shu Liu, Xiulong Song, Tianfei Hou, Xufang Mu, Ming Cui Gong, Zhenheng Guo
  • SNW1, a Novel Transcriptional Regulator of the NF-κB Pathway
    Research Article
    SNW1, a Novel Transcriptional Regulator of the NF-κB Pathway

    The nuclear factor kappa B (NF-κB) family of transcription factors plays a central role in coordinating the expression of genes that control inflammation, immune responses, cell proliferation, and a variety of other biological processes. In an attempt to identify novel regulators of this pathway, we performed whole-genome RNA interference (RNAi) screens in physiologically relevant human macrophages in response to lipopolysaccharide and...

    Suneer Verma, Paul De Jesus, Sumit K. Chanda, Inder M. Verma
  • Research Article
    Transcription Activation Domains of the Yeast Factors Met4 and Ino2: Tandem Activation Domains with Properties Similar to the Yeast Gcn4 Activator
    Derek Pacheco, Linda Warfield, Michelle Brajcich, Hannah Robbins, Jie Luo, Jeff Ranish, Steven Hahn
  • Research Article
    The N-Terminal CCHC Zinc Finger Motif Mediates Homodimerization of Transcription Factor BCL11B
    Piotr Grabarczyk, Passorn Winkler, Martin Delin, Praveen K. Sappa, Sander Bekeschus, Petra Hildebrandt, Grzegorz K. Przybylski, Uwe Völker, Elke Hammer, Christian A. Schmidt
  • Research Article
    CREBH Maintains Circadian Glucose Homeostasis by Regulating Hepatic Glycogenolysis and Gluconeogenesis
    Hyunbae Kim, Ze Zheng, Paul D. Walker, Gregory Kapatos, Kezhong Zhang

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