tristetraprolin
Research Article | SpotlightImportance of the Conserved Carboxyl-Terminal CNOT1 Binding Domain to Tristetraprolin Activity In VivoTristetraprolin (TTP) is an anti-inflammatory protein that modulates the stability of certain cytokine/chemokine mRNAs. After initial high-affinity binding to AU-rich elements in 3′ untranslated regions of target mRNAs, mediated through its tandem zinc finger (TZF) domain, TTP promotes the deadenylation and ultimate decay of target transcripts.