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tristetraprolin

  • Importance of the Conserved Carboxyl-Terminal CNOT1 Binding Domain to Tristetraprolin Activity <em>In Vivo</em>
    Research Article | Spotlight
    Importance of the Conserved Carboxyl-Terminal CNOT1 Binding Domain to Tristetraprolin Activity In Vivo

    Tristetraprolin (TTP) is an anti-inflammatory protein that modulates the stability of certain cytokine/chemokine mRNAs. After initial high-affinity binding to AU-rich elements in 3′ untranslated regions of target mRNAs, mediated through its tandem zinc finger (TZF) domain, TTP promotes the deadenylation and ultimate decay of target transcripts.

    Wi S. Lai, Deborah J. Stumpo, Melissa L. Wells, Artiom Gruzdev, Stephanie N. Hicks, Cindo O. Nicholson, Zhengfeng Yang, Roberta Faccio, Michael W. Webster, Lori A. Passmore, Perry J. Blackshear
  • Open Access
    Research Article
    Gain-of-Function Mutation of Tristetraprolin Impairs Negative Feedback Control of Macrophages In Vitro yet Has Overwhelmingly Anti-Inflammatory Consequences In Vivo
    John D. O'Neil, Ewan A. Ross, Michael L. Ridley, Qize Ding, Tina Tang, Dalya R. Rosner, Thomas Crowley, Deepak Malhi, Jonathan L. Dean, Tim Smallie, Christopher D. Buckley, Andrew R. Clark
  • Open Access
    Research Article
    Beta Interferon Production Is Regulated by p38 Mitogen-Activated Protein Kinase in Macrophages via both MSK1/2- and Tristetraprolin-Dependent Pathways
    Victoria A. McGuire, Dalya Rosner, Olga Ananieva, Ewan A. Ross, Suzanne E. Elcombe, Shaista Naqvi, Mirjam M. W. van den Bosch, Claire E. Monk, Tamara Ruiz-Zorrilla Diez, Andrew R. Clark, J. Simon C. Arthur
  • Articles
    Stimulation of Polo-Like Kinase 3 mRNA Decay by Tristetraprolin
    Thierry J. Horner, Wi S. Lai, Deborah J. Stumpo, Perry J. Blackshear
  • Articles
    Novel mRNA Targets for Tristetraprolin (TTP) Identified by Global Analysis of Stabilized Transcripts in TTP-Deficient Fibroblasts
    Wi S. Lai, Joel S. Parker, Sherry F. Grissom, Deborah J. Stumpo, Perry J. Blackshear
  • Articles
    Glucocorticoids Regulate Tristetraprolin Synthesis and Posttranscriptionally Regulate Tumor Necrosis Factor Alpha Inflammatory Signaling
    Kathleen Smoak, John A. Cidlowski
  • Articles
    Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Regulates Tumor Necrosis Factor mRNA Stability and Translation Mainly by Altering Tristetraprolin Expression, Stability, and Binding to Adenine/Uridine-Rich Element
    Edward Hitti, Tatiana Iakovleva, Matthew Brook, Stefanie Deppenmeier, Achim D. Gruber, Danuta Radzioch, Andrew R. Clark, Perry J. Blackshear, Alexey Kotlyarov, Matthias Gaestel
  • Articles
    Posttranslational Regulation of Tristetraprolin Subcellular Localization and Protein Stability by p38 Mitogen-Activated Protein Kinase and Extracellular Signal-Regulated Kinase Pathways
    Matthew Brook, Carmen R. Tchen, Tomas Santalucia, Joanne McIlrath, J. Simon C. Arthur, Jeremy Saklatvala, Andrew R. Clark
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