TXNIP

  • Ras Suppresses TXNIP Expression by Restricting Ribosome Translocation
    Research Article | Spotlight
    Ras Suppresses TXNIP Expression by Restricting Ribosome Translocation

    Oncogenic Ras upregulates aerobic glycolysis to meet the bioenergetic and biosynthetic demands of rapidly growing cells. In contrast, thioredoxin-interacting protein (TXNIP) is a potent inhibitor of glucose uptake and is frequently downregulated in human cancers.

    Zhizhou Ye, Donald E. Ayer
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