TXNIP

  • Alternative Splicing and Cleavage of GLUT8
    Research Article
    Alternative Splicing and Cleavage of GLUT8

    The GLUT (SLC2) family of membrane-associated transporters are described as glucose transporters. However, this family is divided into three classes and, though the regulated transporter activity of class I proteins is becoming better understood, class III protein functions continue to be obscure. We have cataloged the relative expression and splicing of SLC2 mRNA isomers in tumors and normal tissues, with a focus on...

    Caroline M. Alexander, Joshua A. Martin, Elias Oxman, Ildiko Kasza, Katherine A. Senn, Heidi Dvinge
  • Ras Suppresses TXNIP Expression by Restricting Ribosome Translocation
    Research Article | Spotlight
    Ras Suppresses TXNIP Expression by Restricting Ribosome Translocation

    Oncogenic Ras upregulates aerobic glycolysis to meet the bioenergetic and biosynthetic demands of rapidly growing cells. In contrast, thioredoxin-interacting protein (TXNIP) is a potent inhibitor of glucose uptake and is frequently downregulated in human cancers.

    Zhizhou Ye, Donald E. Ayer
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