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ubiquitination

  • Mutant p53 Sequestration of the MDM2 Acidic Domain Inhibits E3 Ligase Activity
    Research Article | Spotlight
    Mutant p53 Sequestration of the MDM2 Acidic Domain Inhibits E3 Ligase Activity

    Missense p53 mutants often accumulate in tumors and drive progression through gain of function. MDM2 efficiently degrades wild-type p53 but fails to degrade mutant p53 in tumor cells.

    Leixiang Yang, Tanjing Song, Qian Cheng, Lihong Chen, Jiandong Chen
  • Research Article
    Monoubiquitination of Cancer Stem Cell Marker CD133 at Lysine 848 Regulates Its Secretion and Promotes Cell Migration

    CD133, a widely known marker of cancer stem cells, was recently found in extracellular vesicles. However, the mechanisms underlying CD133 translocation to the extracellular space remain largely unknown.

    Fan Yang, Yang Xing, Yinan Li, Xiaoning Chen, Jianhai Jiang, Zhilong Ai, Yuanyan Wei
  • Open Access
    Research Article
    NTH1 Is a New Target for Ubiquitylation-Dependent Regulation by TRIM26 Required for the Cellular Response to Oxidative Stress
    Sarah C. Williams, Jason L. Parsons
  • Research Article
    SUMO Modification of the RNA-Binding Protein La Regulates Cell Proliferation and STAT3 Protein Stability
    Venkatesh Kota, Gunhild Sommer, E. Starr Hazard, Gary Hardiman, Jeffery L. Twiss, Tilman Heise
  • Research Article
    VprBP/DCAF1 Regulates the Degradation and Nonproteolytic Activation of the Cell Cycle Transcription Factor FoxM1
    Xianxi Wang, Anthony Arceci, Kelly Bird, Christine A. Mills, Rajarshi Choudhury, Jennifer L. Kernan, Chunxiao Zhou, Victoria Bae-Jump, Albert Bowers, Michael J. Emanuele
  • Research Article | Spotlight
    The PP2A-B56 Phosphatase Opposes Cyclin E Autocatalytic Degradation via Site-Specific Dephosphorylation
    Ryan J. Davis, Jherek Swanger, Bridget T. Hughes, Bruce E. Clurman
  • Research Article | Spotlight
    FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells
    Takayoshi Yamauchi, Masaaki Nishiyama, Toshiro Moroishi, Atsuki Kawamura, Keiichi I. Nakayama
  • Research Article | Spotlight
    TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS
    Young Bong Choi, Noula Shembade, Kislay Parvatiyar, Siddharth Balachandran, Edward William Harhaj
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