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Latest Articles

  • Free
    Articles of Significant Interest in This Issue
    Spotlight
    Articles of Significant Interest in This Issue
  • An F-Box Protein, Mdm30, Interacts with TREX Subunit Sub2 To Regulate Cellular Abundance Cotranscriptionally in Orchestrating mRNA Export Independently of Splicing and Mitochondrial Function
    Research Article
    An F-Box Protein, Mdm30, Interacts with TREX Subunit Sub2 To Regulate Cellular Abundance Cotranscriptionally in Orchestrating mRNA Export Independently of Splicing and Mitochondrial Function

    Although an F-box protein, Mdm30, is found to regulate ubiquitylation of the Sub2 component of TREX (transcription-export) complex for proteasomal degradation in stimulation of mRNA export, it remains unknown whether such ubiquitin-proteasome system (UPS) regulation of Sub2 occurs cotranscriptionally via its interaction with Mdm30. Further, it is unclear whether impaired UPS...

    Jannatul Ferdoush, Rwik Sen, Geetha Durairaj, Priyanka Barman, Amala Kaja, Shalini Guha, Sukesh R. Bhaumik
  • Unraveling the Hierarchy of <em>cis</em> and <em>trans</em> Factors That Determine the DNA Binding by Peroxisome Proliferator-Activated Receptor γ
    Research Article | Spotlight
    Unraveling the Hierarchy of cis and trans Factors That Determine the DNA Binding by Peroxisome Proliferator-Activated Receptor γ

    Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor essential for adipocyte development and the maintenance of the alternatively polarized macrophage phenotype. Biochemical studies have established that as an obligate heterodimer with retinoid X receptor (RXR), PPARγ binds directly repeated nuclear receptor half sites spaced by one nucleotide (direct repeat 1 [DR1]). However, it has not been analyzed...

    Gergely Nagy, Bence Daniel, Ixchelt Cuaranta-Monroy, Laszlo Nagy
  • EHD1 and RUSC2 Control Basal Epidermal Growth Factor Receptor Cell Surface Expression and Recycling
    Research Article
    EHD1 and RUSC2 Control Basal Epidermal Growth Factor Receptor Cell Surface Expression and Recycling

    Epidermal growth factor receptor (EGFR) is a prototype receptor tyrosine kinase and an oncoprotein in many solid tumors. Cell surface display of EGFR is essential for cellular responses to its ligands. While postactivation endocytic trafficking of EGFR has been well elucidated, little is known about mechanisms of basal/preactivation surface display of EGFR. Here, we identify a novel role of the endocytic regulator EHD1 and a potential...

    Eric C. Tom, Insha Mushtaq, Bhopal C. Mohapatra, Haitao Luan, Aaqib M. Bhat, Neha Zutshi, Sukanya Chakraborty, Namista Islam, Priyanka Arya, Timothy A. Bielecki, Fany M. Iseka, Sohinee Bhattacharyya, Luke R. Cypher, Benjamin T. Goetz, Simarjeet K. Negi, Matthew D. Storck, Sandeep Rana, Angelika Barnekow, Pankaj K. Singh, Guoguang Ying, Chittibabu Guda, Amarnath Natarajan, Vimla Band, Hamid Band
  • Open Access
    A Redox-Sensitive Thiol in Wis1 Modulates the Fission Yeast Mitogen-Activated Protein Kinase Response to H<sub>2</sub>O<sub>2</sub> and Is the Target of a Small Molecule
    Research Article
    A Redox-Sensitive Thiol in Wis1 Modulates the Fission Yeast Mitogen-Activated Protein Kinase Response to H2O2 and Is the Target of a Small Molecule

    Oxidation of a highly conserved cysteine (Cys) residue located in the kinase activation loop of mitogen-activated protein kinase kinases (MAPKK) inactivates mammalian MKK6. This residue is conserved in the fission yeast Schizosaccharomyces pombe MAPKK Wis1, which belongs to the H2O2-responsive MAPK Sty1 pathway. Here, we show that H2O...

    Johanna J. Sjölander, Agata Tarczykowska, Cecilia Picazo, Itziar Cossio, Itedale Namro Redwan, Chunxia Gao, Carlos Solano, Michel B. Toledano, Morten Grøtli, Mikael Molin, Per Sunnerhagen
  • Open Access
    E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation
    Research Article
    E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation

    The NAD-dependent histone deacetylase sirtuin 2 (SIRT2) plays critical roles in mitosis and cell cycle progression and recently was shown to suppress tumor growth and to be downregulated in several types of cancers. However, the underlying mechanism of SIRT2 downregulation remains unknown. In this study, using bioinformatics, gene expression profiling, protein overexpression approaches, and cell migration assays, we showed that E3...

    Liu Liu, Le Yu, Cheng Zeng, Hua Long, Guangjie Duan, Guobing Yin, Xiaotian Dai, Zhenghong Lin
  • ZFP628 Is a TAF4b-Interacting Transcription Factor Required for Mouse Spermiogenesis
    Research Article | Spotlight
    ZFP628 Is a TAF4b-Interacting Transcription Factor Required for Mouse Spermiogenesis

    TAF4b is a subunit of the TFIID complex that is highly expressed in the ovary and testis and required for mouse fertility. TAF4b-deficient male mice undergo a complex series of developmental defects that result in the inability to maintain long-term spermatogenesis. To decipher the transcriptional mechanisms upon which TAF4b functions in spermatogenesis, we used two-hybrid screening to identify a novel TAF4b-interacting transcriptional...

    Eric A. Gustafson, Kimberly A. Seymour, Kirsten Sigrist, Dirk G. D. E. Rooij, Richard N. Freiman
  • Free
    Articles of Significant Interest in This Issue
    Spotlight
    Articles of Significant Interest in This Issue
  • DEAD Box Protein Family Member DDX28 Is a Negative Regulator of Hypoxia-Inducible Factor 2α- and Eukaryotic Initiation Factor 4E2-Directed Hypoxic Translation
    Research Article
    DEAD Box Protein Family Member DDX28 Is a Negative Regulator of Hypoxia-Inducible Factor 2α- and Eukaryotic Initiation Factor 4E2-Directed Hypoxic Translation

    Hypoxia is a deficiency in oxygen delivery to tissues and is connected to physiological and pathophysiological processes such as embryonic development and cancer. The master regulators of oxygen homeostasis in mammalian cells are the heterodimeric hypoxia-inducible transcription factors 1 and 2 (HIF-1 and HIF-2, respectively). The oxygen-labile HIF-2α subunit has been implicated not only in transcription but also as a regulator of...

    Sonia L. Evagelou, Olivia Bebenek, Erin J. Specker, James Uniacke
  • hnRNP K Supports High-Amplitude D Site-Binding Protein mRNA (<em>Dbp</em> mRNA) Oscillation To Sustain Circadian Rhythms
    Research Article
    hnRNP K Supports High-Amplitude D Site-Binding Protein mRNA (Dbp mRNA) Oscillation To Sustain Circadian Rhythms

    Circadian gene expression is defined by the gene-specific phase and amplitude of daily oscillations in mRNA and protein levels. D site-binding protein mRNA (Dbp mRNA) shows high-amplitude oscillation; however, the underlying mechanism remains elusive. Here, we demonstrate that heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a key regulator that activates Dbp transcription via the poly(C) motif within its...

    Paul Kwangho Kwon, Kyung-Ha Lee, Ji-hyung Kim, Sookil Tae, Seokjin Ham, Young-Hun Jeong, Sung Wook Kim, Byunghee Kang, Hyo-Min Kim, Jung-Hyun Choi, Hee Yi, Hyun-Ok Ku, Tae-Young Roh, Chunghun Lim, Kyong-Tai Kim

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